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Article

Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients.

BMC cancer - 21 Oct 2019

Johansen Amanda Frydendahl Boll, Kassentoft Christine Gaasdal, Knudsen Michael, Laursen Maria Bach, Madsen Anders Husted, Iversen Lene Hjerrild, Sunesen Kåre Gotschalck, Rasmussen Mads Heilskov, Andersen Claus Lindbjerg

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and is a positive predictive marker of immunotherapy, it is routine practice to evaluate the MSI status of resected tumors in CRC patients. MSIsensor is a novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31638937
DOI: 10.1186/s12885-019-6227-7
PMCID: PMC6802299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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