Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.

Human molecular genetics - 5 Nov 2024

Martin Samantha, Katainen Riku, Taira Aurora, Välimäki Niko, Ristimäki Ari, Seppälä Toni, Renkonen-Sinisalo Laura, Lepistö Anna, Tahkola Kyösti, Mattila Anne, Koskensalo Selja, Mecklin Jukka-Pekka, Rajamäki Kristiina, Palin Kimmo, Aaltonen Lauri A

Abstract excerpt

Microsatellite unstable colorectal cancer (MSI-CRC) can arise through germline mutations in mismatch repair (MMR) genes in individuals with Lynch syndrome (LS), or sporadically through promoter methylation of the MMR gene MLH1. Despite the different origins of hereditary and sporadic MSI tumours, their genomic features have not been extensively compared. A prominent feature of MMR-deficient genomes is the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to Germ-Line Mutation

Share to INDEL Mutation

Share to Microsatellite Instability

Share to MutL Protein Homolog 1

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39180486
DOI: 10.1093/hmg/ddae124
PMCID: PMC11540923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.PMID 39180486Read ↗

DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndromeSemantic proximity Read ↗

Colorectal Cancers with Microsatellite Instability Display Unique miRNA ProfilesSemantic proximity Read ↗

Molecular testing for microsatellite instability and DNA mismatch repair defects in hereditary and sporadic colorectal cancers--ready for prime time?Semantic proximity Read ↗

Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability.Semantic proximity Read ↗

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigeneticsSemantic proximity Read ↗

DNA Copy-Number Alterations Underlie Gene Expression Differences between Microsatellite Stable and Unstable Colorectal CancersSemantic proximity Read ↗

Clinical and molecular characterisation of hereditary and sporadic metastatic colorectal cancers harbouring microsatellite instability/DNA mismatch repair deficiency.Semantic proximity Read ↗

Genomic and transcriptomic heterogeneity of colorectal tumours arising in Lynch syndrome.Semantic proximity Read ↗

Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers.Semantic proximity Read ↗

Microsatellite Instability and Mismatch Repair Subclonality in Human Cancers: Biologic Basis, Diagnostic Pitfalls, and Therapeutic Implications With a Focus on Colorectal CancerSemantic proximity Read ↗

Is There a Role for Programmed Death Ligand-1 Testing and Immunotherapy in Colorectal Cancer With Microsatellite Instability? Part I-Colorectal Cancer: Microsatellite Instability, Testing, and Clinical Implications.Semantic proximity Read ↗

High microsatellite instability (MSI-H) colorectal carcinoma: a brief review of predictive biomarkers in the era of personalized medicineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.