Article

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

2024-04-20

Abstract excerpt

While colorectal cancer (CRC) patients with microsatellite instability (MSI) respond well to immunotherapy those with microsatellite stable (MSS) tumors rely on conventional chemotherapy, often with poor outcomes. Both types frequently carry mutations in KRAS or BRAF proto-oncogenes, rendering them more resistant to treatment. New therapeutic biomarkers and treatments remain a clinical need, especially for MSS t...

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Literature Corpus work: 3ebbe9b3-36d9-5263-9fef-ad072c06ad52
DOI: 10.1101/2024.04.17.589725

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