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Article

Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell Function

22 Dec 2014

Abstract excerpt

Type 2 diabetes is characterised by an age-related decline in insulin secretion. We previously identified a 50% age-related decline in mitochondrial DNA (mtDNA) copy number in isolated human islets. The purpose of this study was to mimic this degree of mtDNA depletion in MIN6 cells to determine whether there is a direct impact on insulin secretion. Transcriptional silencing of mitochondrial transcription factor...

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Share to Adipose Tissue and Metabolism
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PMID: 25532126
DOI: 10.1371/journal.pone.0115433

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