Mitochondrial dysfunction and pancreatic islet β‑cell failure (Review)

Abstract excerpt

Pancreatic β‑cells are the only source of insulin in humans. Mitochondria uses pyruvate to produce ATP as an intermediate link between glucose intake and insulin secretion in β‑cells, in a process known as glucose‑stimulated insulin secretion (GSIS). Previous studies have demonstrated that GSIS is negatively regulated by various factors in the mitochondria, including tRNALeu mutations, high p58 expression,...

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