Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure

8 Jul 2022

Abstract excerpt

Abstract Genetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been determined. We investigated the effects of the mitoribosomal gene on β-cell function and glucose homeostasis. Mitoribosomal gene expression was analyzed in datasets from the NCBI GEO website...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35804190
DOI: 10.1038/s12276-022-00797-x

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failurePMID 35804190Read ↗

Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics.Semantic proximity Read ↗

Human Mitoribosome Biogenesis and Its Emerging Links to Disease.Semantic proximity Read ↗

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feedingSemantic proximity Read ↗

Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretionSemantic proximity Read ↗

Mitoribosome Defect in Hepatocellular Carcinoma Promotes an Aggressive Phenotype with Suppressed Immune ReactionSemantic proximity Read ↗

Control of pancreatic islet function and glucose homeostasis by a novel microexon program misregulated in type 2 diabetesSemantic proximity Read ↗

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes riskSemantic proximity Read ↗

The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress.Semantic proximity Read ↗

The pathogenetic role of β-cell mitochondria in type 2 diabetesSemantic proximity Read ↗

Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.Semantic proximity Read ↗

Mitophagy protects beta cells from inflammatory damage in diabetesSemantic proximity Read ↗

Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.