Article
Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes.
Cell metabolism - 14 Jun 2016
Tuomi Tiinamaija, Nagorny Cecilia L F, Singh Pratibha, Bennet Hedvig, Yu Qian, Alenkvist Ida, Isomaa Bo, Östman Bjarne, Söderström Johan, Pesonen Anu-Katriina, Martikainen Silja, Räikkönen Katri, Forsén Tom, Hakaste Liisa, Almgren Peter, Storm Petter, Asplund Olof, Shcherbina Liliya, Fex Malin, Fadista João, Tengholm Anders, Wierup Nils, Groop Leif, Mulder Hindrik
Abstract excerpt
Type 2 diabetes (T2D) is a global pandemic. Genome-wide association studies (GWASs) have identified >100 genetic variants associated with the disease, including a common variant in the melatonin receptor 1 b gene (MTNR1B). Here, we demonstrate increased MTNR1B expression in human islets from risk G-allele carriers, which likely leads to a reduction in insulin release, increasing T2D risk. Accordingly,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.