Article
Transcribing β-cell mitochondria in health and disease.
Molecular metabolism - 1 Sept 2017
Mulder Hindrik
Abstract excerpt
BACKGROUND: The recent genome-wide association studies (GWAS) of Type 2 Diabetes (T2D) have identified the pancreatic β-cell as the culprit in the pathogenesis of the disease. Mitochondrial metabolism plays a crucial role in the processes controlling release of insulin and β-cell mass. This notion implies that mechanisms controlling mitochondrial function have the potential to play a decisive pathogenetic role in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.