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Mitochondrial GWAS and association of nuclear – mitochondrial epistasis with BMI in T1DM patients

7 Jul 2020

Abstract excerpt

BACKGROUND: BMI is a strong indicator of complications from type I diabetes, especially under intensive treatment. METHODS: We have genotyped 435 type 1 diabetics using Illumina Infinium Omni Express Exome-8 v1.4 arrays and performed mitoGWAS on BMI. We identified additive interactions between mitochondrial and nuclear variants in genes associated with mitochondrial functioning MitoCarta2.0 and confirmed and...

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PMID: 32635923
DOI: 10.1186/s12920-020-00752-7

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