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Article

The pathogenetic role of β-cell mitochondria in type 2 diabetes

8 Feb 2018

Abstract excerpt

Mitochondrial metabolism is a major determinant of insulin secretion from pancreatic β-cells. Type 2 diabetes evolves when β-cells fail to release appropriate amounts of insulin in response to glucose. This results in hyperglycemia and metabolic dysregulation. Evidence has recently been mounting that mitochondrial dysfunction plays an important role in these processes. Monogenic dysfunction of mitochondria is a...

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Share to Metabolism, Diabetes, and Cancer
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Share to Pancreatic function and diabetes

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PMID: 29431147
DOI: 10.1530/joe-17-0367

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