Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exon sequencing and association analysis of EPHX1 genetic variants with maintenance warfarin dose in a multiethnic Asian population.

Pharmacogenetics and genomics - 1 Jan 2011

Chan Sze Ling, Thalamuthu Anbupalam, Goh Boon Cher, Chia Kee Seng, Chuah Benjamin, Wong Andrea, Lee Soo Chin

Abstract excerpt

BACKGROUND AND OBJECTIVES: Warfarin inhibits vitamin K epoxide reductase, of which microsomal epoxide hydrolase is a putative member. Several studies have found signals of association with warfarin maintenance dose in the EPHX1 gene. The aim of this study was to determine the effects of EPHX1 variants on warfarin maintenance dose in a multiethnic Asian population. METHODS: We sequenced the exons of EPHX1 using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticoagulants
Share to Chemoprevention

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Epoxide Hydrolases

Share to Genetics, Population

Share to Thromboembolism

Share to Warfarin

Source

Identifiers

PMID: 21192345
DOI: 10.1097/fpc.0b013e328341b68f

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exon sequencing and association analysis of EPHX1 genetic variants with maintenance warfarin dose in a multiethnic Asian population.PMID 21192345Read ↗

Influence of two common polymorphisms in the EPHX1 gene on warfarin maintenance dosage: a meta-analysis.Semantic proximity Read ↗

Effects of EPHX1 rs2260863 polymorphisms on warfarin maintenance dose in very elderly, frail Han-Chinese population.Semantic proximity Read ↗

Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.Semantic proximity Read ↗

Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population.Semantic proximity Read ↗

Polymorphisms of vitamin K-related genes (EPHX1 and VKORC1L1) and stable warfarin doses.Semantic proximity Read ↗

Influence of genetic polymorphisms in cytochrome P450 oxidoreductase on the variability in stable warfarin maintenance dose in Han Chinese.Semantic proximity Read ↗

Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans.Semantic proximity Read ↗

[Impact of six genetic polymorphisms on Warfarin maintenance dose variation in Chinese Han population].Semantic proximity Read ↗

Clinical and genetic factors associated with warfarin maintenance dose in northern Chinese patients with mechanical heart valve replacement.Semantic proximity Read ↗

Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose.Semantic proximity Read ↗

Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population.Semantic proximity Read ↗

Is there a role for MDR1, EPHX1 and protein Z gene variants in modulation of warfarin dosage? a study on a cohort of the Egyptian population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.