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Article

Apolipoprotein E genotype and warfarin dosing among Caucasians and African Americans.

The pharmacogenomics journal - 1 Feb 2008

Kimmel S E, Christie J, Kealey C, Chen Z, Price M, Thorn C F, Brensinger C M, Newcomb C W, Whitehead A S

Abstract excerpt

Warfarin sodium is a vitamin K antagonist that is plagued by large variability in patient response, including higher dose requirements among African Americans. Polymorphisms in the gene encoding apolipoprotein E (APOE) may partly explain this variability by altering transport of vitamin K to the liver. In a prospective cohort study of 232 individuals (52.2% Caucasian and 47.8% African American) initiating...

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Source

Identifiers

PMID: 17325732
DOI: 10.1038/sj.tpj.6500445

Genes

APOE
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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