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Article

Is there a role for MDR1, EPHX1 and protein Z gene variants in modulation of warfarin dosage? a study on a cohort of the Egyptian population.

Molecular diagnosis & therapy - 1 Feb 2014

Issac Marianne Samir Makboul, El-Nahid Maggie S, Wissa Marian Youssry

Abstract excerpt

BACKGROUND: There is considerable inter-individual variability in warfarin dosages necessary to achieve target therapeutic anticoagulation. Polymorphisms in genes, which master warfarin pharmacokinetics and pharmacodynamics, might influence warfarin dose variation. Genes encoding drug transporters, such as human multidrug resistance (MDR1), as well as epoxide hydrolase 1 (EPHX1), which is a putative subunit of...

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Source

Identifiers

PMID: 24092646
DOI: 10.1007/s40291-013-0055-2

Genes

EPHX1
VKORC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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