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Article

Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2011

Zhang Xiuling, Li Lei, Ding Xinxin, Kaminsky Laurence S

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) is required for drug metabolism by all microsomal cytochrome P450 enzymes. The aim of this study was to investigate whether any of the common single nucleotide polymorphisms (SNPs) in the POR gene and its flanking intergenic sequences correlate with interindividual variations in the warfarin maintenance dose (which is determined partly by rates of warfarin metabolism) in...

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Source

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Identifiers

PMID: 21562147
DOI: 10.1124/dmd.111.038836
PMCID: PMC3141882

Genes

POR
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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