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Article

Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population.

Scientific reports - 12 Dec 2017

Cai Liang-Liang, Huang Wen-Qing, Su Zhi-Ying, Ye Hui-Ming, Wang Lian-Sheng, Wu Yuan, Zhang Zhong-Ying, Zhang Wei, Tzeng Chi-Meng

Abstract excerpt

Warfarin is a commonly prescribed and effective oral anticoagulant. Genetic polymorphisms associated with warfarin metabolism and sensitivity have been implicated in the wide inter-individual dose variation that is observed. Several algorithms integrating patients' clinical characteristics and genetic polymorphism information have been explored to predict warfarin dose. However, most of these algorithms could...

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Identifiers

PMID: 29234073
DOI: 10.1038/s41598-017-17731-1
PMCID: PMC5727167

Genes

VKORC1

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