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Article

Interethnic variability of warfarin maintenance requirement is explained by VKORC1 genotype in an Asian population.

Clinical pharmacology and therapeutics - 1 Mar 2006

Lee Soo-Chin, Ng Swee-Siang, Oldenburg Johannes, Chong Pei-Yi, Rost Simone, Guo Jia-Yi, Yap Hui-Ling, Rankin Sheila Clare, Khor Hui-Boon, Yeo Tiong-Cheng, Ng Kheng-Siang, Soong Richie, Goh Boon-Cher

Abstract excerpt

BACKGROUND: Chinese and Malay subjects have been reported to require less maintenance warfarin than Indians that could not be accounted for by cytochrome P450 (CYP) 2C9 variants. Vitamin K epoxide reductase complex 1 (VKORC1) is the target enzyme of warfarin, and VKORC1 intronic variants and haplotypes have recently been shown to influence VKORC1 activity and warfarin requirements. METHODS: We sequenced the...

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Source

Identifiers

PMID: 16513444
DOI: 10.1016/j.clpt.2005.11.006

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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