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Article

The neuroanatomical substrate of lexical-semantic decline in MCI APOE ε4 carriers and noncarriers.

Alzheimer disease and associated disorders - 1 Jan 2000

Venneri Annalena, McGeown William J, Biundo Roberta, Mion Marco, Nichelli Paolo, Shanks Michael F

Abstract excerpt

Lexical-semantic competency in mild cognitive impairment (MCI) ε4 carriers was used as an endophenotype, and gray matter volume in MCI ε4 carriers/noncarriers and in noncarrier controls was compared. Residual gray matter volumes were correlated with age of acquisition values for words from a category fluency task, an index of semantic competency. MCI patients had significantly impoverished lexical-semantic output...

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Source

Identifiers

PMID: 21192234
DOI: 10.1097/WAD.0b013e318206f88c

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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