APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease.

doi:10.3233/JAD-130326

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Article

APOE-dependent phenotypes in subjects with mild cognitive impairment converting to Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Morgen Katrin, Frölich Lutz, Tost Heike, Plichta Michael M, Kölsch Heike, Rakebrandt Fabian, Rienhoff Otto, Jessen Frank, Peters Oliver, Jahn Holger, Luckhaus Christian, Hüll Michael, Gertz Hermann-Josef, Schröder Johannes, Hampel Harald, Teipel Stefan J, Pantel Johannes, Heuser Isabella, Wiltfang Jens, Rüther Eckart, Kornhuber Johannes, Maier Wolfgang, Meyer-Lindenberg Andreas

Abstract excerpt

BACKGROUND: The E4 isoform of the APOE genotype is the most significant genetic risk factor for sporadic Alzheimer's disease (AD) and has recently been found to modulate disease expression in patients with AD. OBJECTIVE: To investigate APOE-dependent cognitive and structural phenotypes in subjects with mild cognitive impairment who converted to AD within the following three years. METHODS: Subjects converting to...

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PMID: 23948881
DOI: 10.3233/JAD-130326

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