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Association Between Hippocampus, Thalamus, and Caudate in Mild Cognitive Impairment APOEε4 Carriers: A Structural Covariance MRI Study

20 Dec 2019

Abstract excerpt

Objective: Despite the Apolipoprotein E (APOE) genotype is widely recognized as one of the most important risk factors for Alzheimer’s Disease (AD) development, the neural mechanisms by which the ε4 allele promote the AD occurring remain under debate. The aim of this study was to evaluate neurobiological effects of the APOE-genotype on the pattern of the structural covariance in mild cognitive impairment (MCI)...

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PMID: 31920926
DOI: 10.3389/fneur.2019.01303

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