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Article

Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume.

Psychological medicine - 1 Sept 2011

Striepens N, Scheef L, Wind A, Meiberth D, Popp J, Spottke A, Kölsch H, Wagner M, Jessen F

Abstract excerpt

BACKGROUND: The apolipoprotein E4 allele (ApoE4) is an established genetic risk factor for Alzheimer's disease (AD). However, its effects on cognitive performance and brain structure in healthy individuals are complex. We investigated the effect of ApoE4 on cognitive performance and medial temporal lobe volumetric measures in cognitively unimpaired young elderly with and without subjective memory impairment...

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Identifiers

PMID: 21284913
DOI: 10.1017/S0033291711000067

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