Article
APOE-ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2018
Saeed Usman, Mirza Saira S, MacIntosh Bradley J, Herrmann Nathan, Keith Julia, Ramirez Joel, Nestor Sean M, Yu Qinggang, Knight Jo, Swardfager Walter, Potkin Steven G, Rogaeva Ekaterina, St George-Hyslop Peter, Black Sandra E, Masellis Mario
Abstract excerpt
INTRODUCTION: Although the apolipoprotein E ε4-allele (APOE-ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. METHODS: We studied 298 patients (AD = 250, DLB = 48; 38 autopsy-confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance...
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