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Article

Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes.

Neurology - 13 Jul 1999

Caselli R J, Graff-Radford N R, Reiman E M, Weaver A, Osborne D, Lucas J, Uecker A, Thibodeau S N

Abstract excerpt

OBJECTIVE: To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype. BACKGROUND: The apoE-4 allele is an important risk factor for AD. PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral metabolism suggestive of very early AD that precedes clinically evident memory loss or MRI-based...

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Source

Identifiers

PMID: 10408560
DOI: 10.1212/wnl.53.1.201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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