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Article

Temperature-sensitive DNA mutant of Chinese hamster ovary cells with a thermolabile ribonucleotide reductase activity.

Molecular and cellular biology - 1 Nov 1990

Wojcik B E, Dermody J J, Ozer H L, Mun B, Mathews C K

Abstract excerpt

JB3-B is a Chinese hamster ovary cell mutant previously shown to be temperature sensitive for DNA replication (J. J. Dermody, B. E. Wojcik, H. Du, and H. L. Ozer, Mol. Cell. Biol. 6:4594-4601, 1986). It was chosen for detailed study because of its novel property of inhibiting both polyomavirus and adenovirus DNA synthesis in a temperature-dependent manner. Pulse-labeling studies demonstrated a defect in the rate...

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Identifiers

PMID: 2233712
DOI: 10.1128/mcb.10.11.5688-5699.1990
PMCID: PMC361336

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