Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.

doi:10.1074/jbc.273.46.30069

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Article

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.

The Journal of biological chemistry - 13 Nov 1998

Shieh W M, Amé J C, Wilson M V, Wang Z Q, Koh D W, Jacobson M K, Jacobson E L

Abstract excerpt

Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated in response to DNA strand breaks and functions in the maintenance of genomic integrity. Mice homozygous for a disrupted gene encoding PARP are viable but have severe s...

Topics

3T3 Cells
Animals
Chromatography, High Pressure Liquid
Genotype
Methylnitronitrosoguanidine
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutagens
NAD
Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases

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