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Article

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.

The Journal of biological chemistry - 13 Nov 1998

Shieh W M, Amé J C, Wilson M V, Wang Z Q, Koh D W, Jacobson M K, Jacobson E L

Abstract excerpt

Poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30), the only enzyme known to synthesize ADP-ribose polymers from NAD+, is activated in response to DNA strand breaks and functions in the maintenance of genomic integrity. Mice homozygous for a disrupted gene encoding PARP are viable but have severe sensitivity to gamma-radiation and alkylating agents. We demonstrate here that both 3T3 and primary embryo cells derived...

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PMID: 9804757
DOI: 10.1074/jbc.273.46.30069

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