Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A weakly tumorigenic phenotype with high MHC class-I expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma.

International journal of cancer - 15 Aug 1990

Pérez M, Algarra I, Ljunggren H G, Caballero A, Mialdea M J, Gaforio J J, Klein G, Kärre K, Garrido F

Abstract excerpt

We have examined the metastatic capacity of different clones of a chemically induced fibrosarcoma GR9. These clones have previously been characterized for their H-2 class-I and class-II phenotype, NK sensitivity and local tumor growth. Our present data show that clones which express low amounts of H-2 class-I antigens are poorly metastatic in a post-surgical spontaneous metastasis assay, while those expressing...

Topics

Animals
Clone Cells
Fibrosarcoma
H-2 Antigens
Histocompatibility Antigens Class I
Interferon-gamma
Lung Neoplasms
Methylcholanthrene
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Phenotype

Postoperative Period

Recombinant Proteins

Tumor Cells, Cultured

Source

Identifiers

PMID: 2116997
DOI: 10.1002/ijc.2910460219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2116997-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A weakly tumorigenic phenotype with high MHC class-I expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma.PMID 2116997Read ↗

Selective upregulation of MHC class I expression in metastatic colonies derived from tumor clones of a murine fibrosarcoma.Semantic proximity Read ↗

Heterogeneity of MHC-class-I antigens in clones of methylcholanthrene-induced tumors. Implications for local growth and metastasis.Semantic proximity Read ↗

Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants.Semantic proximity Read ↗

Resistance to NK and metastatic potential of fibrosarcoma cells is associated with products encoded by the H-2D region.Semantic proximity Read ↗

NK sensitivity, H-2 expression and metastatic potential: analysis of H-2Dk gene transfected fibrosarcoma cells.Semantic proximity Read ↗

H-2Kb transfection of B16 melanoma cells results in reduced tumourigenicity and metastatic competence.Semantic proximity Read ↗

MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to ImmunotherapySemantic proximity Read ↗

MHC class I genes controlling the metastatic phenotype of tumor cells.Semantic proximity Read ↗

H-2Kb and H-2Db gene transfections in B16 melanoma differently affect non-immunological properties relevant to the metastatic process. Involvement of integrin molecules.Semantic proximity Read ↗

Combined vaccination with major histocompatibility class I and interleukin 2 gene-transduced melanoma cells synergizes the cure of postsurgical established lung metastases.Semantic proximity Read ↗

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.Semantic proximity Read ↗

Changes in the coding sequence of the H-2Dk gene of metastatic cells that might account for immunogenic abnormality of its encoded antigen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.