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Article

MHC class I genes controlling the metastatic phenotype of tumor cells.

Seminars in cancer biology - 1 Oct 1991

Feldman M, Eisenbach L

Abstract excerpt

Metastatic clones of murine tumors that manifest impaired expression of class I MHC antigens do not induce an antitumor CTL activity. Transfection of H-2Kb genes into D122 carcinoma and B16 melanoma clones converted these cells to low metastatic immunogenic clones that can be used to protect in vivo against metastases of parental clones. Amplification of the protective effect can be achieved by combination of...

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PMID: 1773049

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