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Article

MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy

28 Jan 2018

Abstract excerpt

An individual tumor can present intratumoral phenotypic heterogeneity, containing tumor cells with different phenotypes that do not present irreversible genetic alterations. We have developed a mouse cancer model, named GR9, derived from a methylcholanthrene-induced fibrosarcoma that was adapted to tissue culture and cloned into different tumor cell lines. The clones showed diverse MHC-I phenotypes, ranging from...

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PMID: 29434605
DOI: 10.3389/fimmu.2018.00102

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