Article
Resistance to NK and metastatic potential of fibrosarcoma cells is associated with products encoded by the H-2D region.
Seminars in cancer biology - 1 Oct 1991
Rager-Zisman B, Aboud M, Gopas J, Har-Vardi I, Hämmerling G J, Segal S
Abstract excerpt
We have used the murine 3-methylcholanthrene induced T10 fibrosarcoma tumor cell system originating in (C3II/en x C57BL/6)F1 mice (H-2b x H-2k) to elucidate the possible correlation between metastatic potential, expression of individual H-2 antigens and susceptibility to NK cells. Transfection of the non metastatic and NK sensitive IC9 cells (Db+, Kk, Kb, Kk-) with the H-2Dk gene, altered the metastatic phenotype...
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