Combined vaccination with major histocompatibility class I and interleukin 2 gene-transduced melanoma cells synergizes the cure of postsurgical established lung metastases.

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Article

Combined vaccination with major histocompatibility class I and interleukin 2 gene-transduced melanoma cells synergizes the cure of postsurgical established lung metastases.

Cancer research - 1 Nov 1995

Porgador A, Tzehoval E, Vadai E, Feldman M, Eisenbach L

Abstract excerpt

We have analyzed and compared in detail the malignant phenotypes of, the immune mechanisms induced by, and the immunotherapeutic potentials of B16-F10.9 melanoma cells manipulated by gene transfer to express syngeneic H-2Kb molecules or to secrete the cytokines interleukin 2 (IL-2) or IL-6. Local...

Topics

Animals
Gene Transfer Techniques
Genetic Therapy
H-2 Antigens
Immunotherapy, Active
Interleukin-2
Interleukin-6
Killer Cells, Lymphokine-Activated
Killer Cells, Natural
Lung Neoplasms
Melanoma, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred C57BL

Neoplasm Transplantation

Phenotype

Postoperative Complications

T-Lymphocytes, Cytotoxic

Transduction, Genetic

Source

Open in PubMed

Identifiers

PMID: 7585534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7585534-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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