Article
Immunoselection by T lymphocytes generates repeated MHC class I-deficient metastatic tumor variants.
International journal of cancer - 1 Jan 2001
Garcia-Lora A, Algarra I, Gaforio J J, Ruiz-Cabello F, Garrido F
Abstract excerpt
Alteration of MHC class I molecule expression is a widespread mechanism used by tumor cells to evade T cell responses. It has long been proposed that the origin of these MHC class I-negative or -deficient tumor variants is T cell immune selection. However, there are no experimental or clinical data to substantiate this hypothesis, and this issue is currently the subject of debate. Here we report that an H-2 class...
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