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Article

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.

International journal of cancer - 15 Jan 2016

Garrido Federico, Romero Irene, Aptsiauri Natalia, Garcia-Lora Angel M

Abstract excerpt

Intratumor heterogeneity among cancer cells is promoted by reversible or irreversible genetic alterations and by different microenvironmental factors. There is considerable experimental evidence of the presence of a variety of malignant cell clones with a wide diversity of major histocompatibility class I (MHC-I) expression during early stages of tumor development. This variety of MHC-I phenotypes may define the...

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Identifiers

PMID: 25471439
DOI: 10.1002/ijc.29375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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