Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.

doi:10.1002/ijc.29375

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Article

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.

International journal of cancer - 15 Jan 2016

Garrido Federico, Romero Irene, Aptsiauri Natalia, Garcia-Lora Angel M

Abstract excerpt

Intratumor heterogeneity among cancer cells is promoted by reversible or irreversible genetic alterations and by different microenvironmental factors. There is considerable experimental evidence of the presence of a variety of malignant cell clones with a wide diversity of major histocompatibility class I (MHC-I) expression during early stages of tumor development. This variety of MHC-I phenotypes may define the...

Topics

Animals
Histocompatibility Antigens Class I
Humans
Neoplasms
Phenotype
Tumor Escape

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Open in PubMed

Identifiers

PMID: 25471439
DOI: 10.1002/ijc.29375

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