Article
Heterogeneity of MHC-class-I antigens in clones of methylcholanthrene-induced tumors. Implications for local growth and metastasis.
International journal of cancer. Supplement = Journal international du cancer. Supplement - 1 Jan 1991
Algarra I, Gaforio J J, Garrido A, Mialdea M J, Pérez M, Garrido F
Abstract excerpt
We analyzed the H-2 class-I expression of different clones obtained from 4 different methylcholanthrene-induced tumors in BALB/c (H-2d) mice. The results clearly indicated high intra-tumor heterogeneity in all 4 fibrosarcomas with regard to H-2 K, D and L expression. Clones were found to be H-2-n...
Topics
- Animals
- Cell Division
- Cell Line
- Clone Cells
- Cytotoxicity, Immunologic
- DNA, Neoplasm
- Fibrosarcoma
- H-2 Antigens
- Killer Cells, Natural
- Methylcholanthrene
- Mice
- Mice, Inbred BALB C
- Neoplasm Metastasis
- Neoplasm Transplantation
- Nucleic Acid Hybridization
- Phenotype
- Polymerase Chain Reaction
- RNA, Neoplasm