Article
H-2Kb and H-2Db gene transfections in B16 melanoma differently affect non-immunological properties relevant to the metastatic process. Involvement of integrin molecules.
International journal of cancer - 15 Oct 1994
De Giovanni C, Nicoletti G, Sensi M, Santoni A, Palmieri G, Landuzzi L, Nanni P, Lollini P L
Abstract excerpt
Modification of non-immunological cell adhesion properties plays a major role in the decrease in metastatic ability observed after transfection of the H-2Kb gene in H-2-negative B16-derived melanoma clone cells. To investigate the role played by different class-I major histocompatibility complex...
Topics
- Animals
- Cell Adhesion
- Genes, MHC Class I
- H-2 Antigens
- Integrins
- Melanoma, Experimental
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis
- Phenotype
- Transfection