Article
Changes in the coding sequence of the H-2Dk gene of metastatic cells that might account for immunogenic abnormality of its encoded antigen.
Biochemical and biophysical research communications - 28 Sept 1990
Aboud M, Askenazi-Rydel M, Har-Vardi I, Weinstein Y, Gopas J, Segal S
Abstract excerpt
In previous studies we have demonstrated that metastatic cells, derived from T-10 fibrosarcoma, express an immunogenically abnormal H-2Dk glycoprotein which is involved in manifesting their metastatic phenotype. In the present study we show that these cells contain a remarkably high level of H-2Dk specific mRNA. Moreover, by cloning cDNA of this gene and analyzing its nucleotide sequence, we found 4 single...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Fibrosarcoma
- Genes, MHC Class I
- H-2 Antigens
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation