Article
Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
Japanese journal of cancer research : Gann - 1 May 1990
Sakai H, Ogawa K
Abstract excerpt
We examined mutational activation of H- and K-ras genes in hyperplastic nodules and hepatocellular carcinomas induced by N-nitroso-N-methylurea or diethylnitrosamine using the polymerase chain reaction, followed by dot-blot hybridization. No mutational activation was detected in these hepatic lesions. The results indicate that low incidence of the activation of H- and K-ras genes in rat liver tumors is due to the...
Topics
- Animals
- Diethylnitrosamine
- Genes, ras
- Liver Neoplasms, Experimental
- Male
- Methylnitrosourea
- Mutation
- Polymerase Chain Reaction
- Rats
- Rats, Inbred F344