Article
Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Carcinogenesis - 1 Dec 1991
Rumsby P C, Barrass N C, Phillimore H E, Evans J G
Abstract excerpt
In a study of the mechanisms involved in the induction of tumours by chemicals, the Ha-ras oncogene was analysed in liver tumours induced by the genotoxic carcinogen diethylnitrosamine (DEN), or the non-genotoxic agent phenobarbitone (PB) in C3H/He mice. Mutations were detected using the polymera...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Codon
- DNA
- Diethylnitrosamine
- Gene Expression
- Genes, ras
- Immunoblotting
- Liver Neoplasms, Experimental
- Methylation
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Phenobarbital
- RNA, Neoplasm