Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.

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Article

Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.

Cancer research - 15 Feb 1991

Candrian U, You M, Goodrow T, Maronpot R R, Reynolds S H, Anderson M W

Abstract excerpt

The C57BL/6 x C3H F1 (hereafter called B6C3F1) mouse is an important animal model for long-term carcinogenesis studies. Maintained under normal laboratory conditions, these mice develop various types of spontaneous tumors during their lifetime. Activated Ha-ras genes have been detected in 66% of spontaneous hepatocellular tumors in the B6C3F1 mouse [Reynolds et al., Science (Washington DC), 237:1309, 1988]. In...

Topics

Adenocarcinoma
Animals
Base Sequence
Blotting, Southern
Cell Transformation, Neoplastic
Gene Expression Regulation, Neoplastic
Hemangiosarcoma
Intestinal Neoplasms
Liver Neoplasms
Lung Neoplasms
Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Neoplasms, Experimental

Nucleic Acid Hybridization

Polymerase Chain Reaction

Proto-Oncogenes

Source

Open in PubMed

Identifiers

PMID: 1997158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1997158-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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