Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.

doi:10.1007/BF01612755

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Article

Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.

Journal of cancer research and clinical oncology - 1 Jan 1991

Ostermayr R, Suchy B, Rabes H M

Abstract excerpt

We examined mutational activation of ras genes in rat liver preneoplasias and tumours induced by diethylnitrosamine and N-methyl-N-nitrosourea (NMU). In accordance with previous reports on H- and K-ras genes, no mutations were detected in the investigated hepatic tumours and prestages suggesting...

Topics

Animals
Base Sequence
Blotting, Southern
Codon
Exons
Gene Expression Regulation
Genes, ras
Introns
Liver
Liver Neoplasms, Experimental
Male
Methylnitrosourea
Molecular Sequence Data
Mutation
Rats
Rats, Inbred Strains

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