Article
The role of wild-type and mutated N-ras in the malignant transformation of liver cells.
Molecular carcinogenesis - 1 May 2000
Schleger C, Heck R, Steinberg P
Abstract excerpt
In order to determine the role of N-ras overexpression and mutation in malignant liver cell transformation, wild-type and mutated N-ras were transfected into the rat liver epithelial cell line OC/CDE 22, and N-ras expression, growth kinetics, growth in soft agar, and tumorigenicity in vivo as well as the involvement of the mitogen-activated protein kinase (MAPK) signal transduction pathway in the expression of...
Topics
- Animals
- Cattle
- Cell Line
- Cell Transformation, Neoplastic
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Liver Neoplasms
- Mutation
- Rats