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Article

The role of wild-type and mutated N-ras in the malignant transformation of liver cells.

Molecular carcinogenesis - 1 May 2000

Schleger C, Heck R, Steinberg P

Abstract excerpt

In order to determine the role of N-ras overexpression and mutation in malignant liver cell transformation, wild-type and mutated N-ras were transfected into the rat liver epithelial cell line OC/CDE 22, and N-ras expression, growth kinetics, growth in soft agar, and tumorigenicity in vivo as well as the involvement of the mitogen-activated protein kinase (MAPK) signal transduction pathway in the expression of...

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Identifiers

PMID: 10820486
DOI: 10.1002/(sici)1098-2744(200005)28:1<31::aid-mc5>3.0.co;2-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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