Article
Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.
Cancer research - 15 Aug 1999
Tsujiuchi T, Tsutsumi M, Sasaki Y, Takahama M, Konishi Y
Abstract excerpt
To allow a study of beta-catenin mutations in hepatocellular carcinomas (HCCs) induced by exogenous and endogenous carcinogens, we induced tumors in male Fischer 344 rats with N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet. Administration of the former was followed by partial hepatectomy with colchicine to induce cell cycle disturbance and a selection pressure regimen (K. Ohashi et al.,...
Topics
- Amino Acids
- Animals
- Carcinogens
- Choline Deficiency
- Cytoskeletal Proteins
- Diet
- Diethylnitrosamine
- Liver Neoplasms, Experimental
- Male
- Mutagens
- Mutation