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Article

Chemical carcinogens and proto-oncogens activation.

Biochimie - 1 Jan 2000

Laval J, Strauss B S

Abstract excerpt

The induction of proto-oncogens H-ras-1 by nitrosomethylurea (Sukumar et al. (1983), 306, 658-661) is discussed in term of lack of DNA-repair of lesions induced in DNA by this alkylating agent, particularly O6-methylguanine residues and apurinic/apyrimidinic sites.

Topics

Alkylating Agents
Alkylation
Animals
Carcinogens
DNA
DNA Repair
Gene Expression Regulation
Guanine
Humans
Methylation
Mutation
Neoplasms
Oncogenes

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Identifiers

PMID: 3899192
DOI: 10.1016/s0300-9084(85)80086-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3899192-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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