Article
Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
Carcinogenesis - 1 Feb 1991
Devereux T R, Anderson M W, Belinsky S A
Abstract excerpt
The role of ras activation in the formation of spontaneous and chemically induced tumors was evaluated in the C3H mouse, a strain that has a low incidence of spontaneous lung tumors. Lung tumors were induced in C3H mice by treatment with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK),...
Topics
- Animals
- Base Sequence
- Codon
- DNA
- Dimethylnitrosamine
- Drug Resistance
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Guanine
- Incidence
- Lung Neoplasms
- Male
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Nitrosamines
- Proto-Oncogenes