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Article

Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.

Scientific reports - 6 Apr 2017

Peng Gary, Barro-Soria Rene, Sampson Kevin J, Larsson H Peter, Kass Robert S

Abstract excerpt

KCNQ1 is a voltage-gated potassium channel that is modulated by the beta-subunit KCNE1 to generate IKs, the slow delayed rectifier current, which plays a critical role in repolarizing the cardiac action potential. Two KCNQ1 gain-of-function mutations that cause a genetic form of atrial fibrillation, S140G and V141M, drastically slow IKs deactivation. However, the underlying gating alterations remain unknown....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28383569
DOI: 10.1038/srep45911
PMCID: PMC5382920

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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