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Article

Functional Interactions between KCNE1 C-Terminus and the KCNQ1 Channel

1 Apr 2009

Abstract excerpt

The KCNE1 gene product (minK protein) associates with the cardiac KvLQT1 potassium channel (encoded by KCNQ1) to create the cardiac slowly activating delayed rectifier, I(Ks). Mutations throughout both genes are linked to the hereditary cardiac arrhythmias in the Long QT Syndrome (LQTS). KCNE1 exerts its specific regulation of KCNQ1 activation via interactions between membrane-spanning segments of the two...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 19340287
DOI: 10.1371/journal.pone.0005143

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Functional Interactions between KCNE1 C-Terminus and the KCNQ1 ChannelPMID 19340287Read ↗

Physical and functional interaction sites in cytoplasmic domains of KCNQ1 and KCNE1 channel subunits.Semantic proximity Read ↗

Role of the S6 C-terminus in KCNQ1 channel gating.Semantic proximity Read ↗

Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.Semantic proximity Read ↗

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms.Semantic proximity Read ↗

Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.Semantic proximity Read ↗

Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome.Semantic proximity Read ↗

N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome.Semantic proximity Read ↗

Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1.Semantic proximity Read ↗

Functional effects of a KCNQ1 mutation associated with the long QT syndrome.Semantic proximity Read ↗

The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.Semantic proximity Read ↗

KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.Semantic proximity Read ↗

A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome.Semantic proximity Read ↗

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