Article
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling.
BMC bioinformatics - 13 Dec 2010
Bebek Gurkan, Patel Vishal, Chance Mark R
Abstract excerpt
BACKGROUND: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified over the years, it is not always clear which functions or interactions are operative in a particular tumor. This is confounded by the presence of mutations in a number of other putative cancer driver (CAN) genes, which often synergize with...
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