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Article

One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis.

Cancer research - 15 Sept 2008

Yeung Anthony T, Patel Bhavinkumar B, Li Xin-Ming, Seeholzer Steven H, Coudry Renata A, Cooper Harry S, Bellacosa Alfonso, Boman Bruce M, Zhang Tao, Litwin Samuel, Ross Eric A, Conrad Peggy, Crowell James A, Kopelovich Levy, Knudson Alfred

Abstract excerpt

We studied patients with Familial Adenomatous Polyposis (FAP) because they are virtually certain to develop colon cancer, and because much is known about the causative APC gene. We hypothesized that the inherited heterozygous mutation itself leads to changes in the proteome of morphologically normal crypts and the proteins that changed may represent targets for preventive and therapeutic agents. We determined the...

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Share to Adenomatous Polyposis Coli
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Genes, APC

Share to Intestinal Mucosa

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Source

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Identifiers

PMID: 18794146
DOI: 10.1158/0008-5472.CAN-08-0856
PMCID: PMC2562578

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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