Toponome Imaging System: <i>In Situ</i> Protein Network Mapping in Normal and Cancerous Colon from the Same Patient Reveals More than Five-Thousand Cancer Specific Protein Clusters and Their Subcellular Annotation by Using a Three Symbol Code

Abstract excerpt

In a proof of principle study, we have applied an automated fluorescence toponome imaging system (TIS) to examine whether TIS can find protein network structures, distinguishing cancerous from normal colon tissue present in a surgical sample from the same patient. By using a three symbol code and a power of combinatorial molecular discrimination (PCMD) of 2(21) per subcellular data point in one single tissue...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bioinformatics and Genomic Networks
• Share to Cancer Cells and Metastasis