Article

A targeted genetic modifier screen in Drosophila uncovers vulnerabilities in a genetically complex model of colon cancer

2022-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Kinases are key regulators of cellular signal transduction pathways. Many diseases including cancer are associated with global alterations in protein phosphorylation networks, as a result, kinases are frequent targets of drug discovery efforts. However, target identification and assessment, a critical step in targeted drug discovery which involves identifying essential genetic mediators of disea...

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Literature Corpus work: 3b1d7d8b-294c-5e87-84ff-3101b2350c6a
DOI: 10.1101/2022.09.23.508936

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