Article
PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc Min-Triggered Intestinal Tumor Formation.
Cancer research - 1 Jan 2021
Farrall Alexandra L, Lienhard Matthias, Grimm Christina, Kuhl Heiner, Sluka Susanna H M, Caparros Marta, Forejt Jiri, Timmermann Bernd, Herwig Ralf, Herrmann Bernhard G, Morkel Markus
Abstract excerpt
Genetic predisposition affects the penetrance of tumor-initiating mutations, such as APC mutations that stabilize β-catenin and cause intestinal tumors in mice and humans. However, the mechanisms involved in genetically predisposed penetrance are not well understood. Here, we analyzed tumor multiplicity and gene expression in tumor-prone Apc Min/+ mice on highly variant C57BL/6J (B6) and PWD/Ph (PWD) genetic...
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