Article

Identification of endogenous Adenomatous polyposis coli interaction partners and β-catenin-independent targets by proteomics

2018-02-01

Abstract excerpt

<h4>Summary</h4> Adenomatous polyposis coli ( APC ) is the most frequently mutated gene in colorectal cancer. APC negatively regulates the pro-proliferative Wnt signaling pathway by promoting the degradation of β-catenin, but the extent to which APC exerts Wnt/β-catenin-independent tumor suppressive activity is unclear. To identify interaction partners and β-catenin-independent targets of endogenous, full-length...

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Literature Corpus work: 66c02ff7-4a68-56d4-867c-4e62eebcd8f3
DOI: 10.1101/258400

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